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skos:definition |
NCI: Encoded by human RET Gene, Tyrosine-Protein Kinase Receptor RET is a type I membrane protein receptor for Glial Cell Line-Derived Neurotrophic Factor with an extracellular cadherin-like domain and important in neural crest development. Activation of the RET kinase results in autophosphorylation of tyrosine residues critical for signaling. RET mutations are associated with Hirschsprung's disease and Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer.
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