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skos:definition |
NCI: Expressed as 2 alternative isoforms in monocytes and dendritic cells by human SIRPB1 Gene (SIRPB Family/Ig Family), N-glycosylated 398-aa 43-kDa (precursor) type I membrane protein Signal-Regulatory Protein Beta 1 is a cell surface Ig-like transmembrane receptor glycoprotein containing an IgV-type domain and 2 IgC1-type domains involved in negative regulation of receptor tyrosine kinase-coupled signaling. Unlike SIRPAs, SIRPB1 lacks a C-terminal cytoplasmic SHP2-binding domain. SIRPB1 interacts with ITAM protein TYROBP/DAP12, resulting in SYK tyrosine kinase recruitment. (NCI)
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