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calbc:hasCorrelation | |
skos:definition |
NCI: A bacterial toxic substance linked to an antibody that attaches to cancer cells and kills them. It belongs to the family of drugs called bacterial immunotoxins.,PDQ: A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43322&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43322&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1842" NCI Thes
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skos:inScheme | |
skos:broader | |
skos-xl:prefLabel | |
skos-xl:altLabel |
umls-label:A10773623,
umls-label:A11914512,
umls-label:A11916139,
umls-label:A11916140,
umls-label:A1707903,
umls-label:A2039718,
umls-label:A4356292,
umls-label:A4358100,
umls-label:A4358325,
umls-label:A7582391,
umls-label:A7636137,
umls-label:A7650042,
umls-label:A7660228,
umls-label:A7664575,
umls-label:A7668577
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R128619249,
http://linkedlifedata.com/resource/umls/relation/R128619250,
http://linkedlifedata.com/resource/umls/relation/R60460658,
http://linkedlifedata.com/resource/umls/relation/R60455693,
http://linkedlifedata.com/resource/umls/relation/R54174786,
http://linkedlifedata.com/resource/umls/relation/R54314806,
http://linkedlifedata.com/resource/umls/relation/R54396967,
http://linkedlifedata.com/resource/umls/relation/R54396968,
http://linkedlifedata.com/resource/umls/relation/R124677509,
http://linkedlifedata.com/resource/umls/relation/R124677510,
http://linkedlifedata.com/resource/umls/relation/R69787610,
http://linkedlifedata.com/resource/umls/relation/R109640700
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