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skos:definition |
NCI: A monoclonal antibody directed against the CD20 protein expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope iodine I 131 with potential antineoplastic activity. Iodine I 131 tositumomab binds to and selectively delivers cyctotoxic radiation to CD20-expressing B-lymphocytes, thereby minimizing systemic radiotoxicity.,NCI: A monoclonal antibody (tositumomab) that has been chemically changed by adding radioactive iodine, and that is used in the treatment of certain types of non-Hodgkin lymphoma. It belongs to the family of drugs called radioconjugated monoclonal antibodies. When iodine I 131 tositumomab and tositumomab are given together, the combination is called the Bexxar regimen.,PDQ: A monoclonal antibody directed against a protein (CD20) expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope I 131 with potential antineoplastic activity. Iodine I 131 tositumomab delivers radiation selectively to neoplastic CD20-expressing B-lymphocytes cells, there
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