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skos:definition |
MSH: An aspect of cholinesterase (EC 3.1.1.8).,NCI: Human butyrylcholinesterase protein (602 aa, 68 kD), a serine esterase, is encoded by the human butyrylcholinesterase (BCHE) gene. This protein, a homotetramer, is present in most cells (except erythrocytes) and catalyzes the hydrolysis of acylcholines to yield a choline and a carboxylate anion. Reduced serum activity of the BCHE protein causes hypocholinesterasemia, a condition resulting in sensitivity to the muscle relaxant suxamethonium, which is commonly used in association with surgical anesthesia.
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