|
rdf:type |
|
|
calbc:hasCorrelation |
|
|
skos:definition |
NCI: A toxic substance linked to an antibody that attaches to tumor cells and kills them.,PDQ: A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted). LMB-2 immunotoxin targets the interleukin 2 receptor (also known as IL-2R or CD25) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies. The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43377&idtype=1" active clinical trials or "http://www.cancer.gov/
|
|
skos:inScheme |
|
|
skos:broader |
|
|
skos-xl:prefLabel |
|
|
skos-xl:altLabel |
umls-label:A0305880,
umls-label:A10773551,
umls-label:A10774674,
umls-label:A11916887,
umls-label:A11917663,
umls-label:A11919313,
umls-label:A11920144,
umls-label:A1926288,
umls-label:A2044819,
umls-label:A4357860,
umls-label:A4359204,
umls-label:A7649258,
umls-label:A7650046,
umls-label:A7651445,
umls-label:A7664783,
umls-label:A7669006
|
|
umls:relation |
http://linkedlifedata.com/resource/umls/relation/R128542582,
http://linkedlifedata.com/resource/umls/relation/R128542583,
http://linkedlifedata.com/resource/umls/relation/R60457869,
http://linkedlifedata.com/resource/umls/relation/R60460674,
http://linkedlifedata.com/resource/umls/relation/R54174788,
http://linkedlifedata.com/resource/umls/relation/R54174787,
http://linkedlifedata.com/resource/umls/relation/R54174789,
http://linkedlifedata.com/resource/umls/relation/R54314813,
http://linkedlifedata.com/resource/umls/relation/R54435901,
http://linkedlifedata.com/resource/umls/relation/R54423155,
http://linkedlifedata.com/resource/umls/relation/R54396977,
http://linkedlifedata.com/resource/umls/relation/R109393500,
http://linkedlifedata.com/resource/umls/relation/R109584051,
http://linkedlifedata.com/resource/umls/relation/R54396978,
http://linkedlifedata.com/resource/umls/relation/R124677514,
http://linkedlifedata.com/resource/umls/relation/R109640770,
http://linkedlifedata.com/resource/umls/relation/R22562934
|
