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skos:definition |
MSH: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.,NCI: Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. Matrix metalloproteinases have been associated with the development of advanced-stage cancer via their role in tumor progression, invasion, and metastasis.
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