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skos:definition |
NCI: Initial studies indicate that hK2 may be better than PSA as a marker of poorly differentiated prostate cancer tumors,NCI: Glandular Kallikrein 2 isoforms 1 (261-aa, 28.7-kD prepropeptide), 2 (PGK-10A, 222-aa), 3 (164-aa) are encoded by human KLK2 Gene (Kallikrein Family). The mature serine protease is 237 amino acids. Glandular kallikreins comprise specific proteases involved in processing active peptides. KLK2 exhibits 66% and 73% homology with KLK1 and APS. Glandular kallikreins release vasoactive peptides from kininogen; the kininogenase activity of different kallikreins is highly variable. Kallikrein 2 cleaves kininogen Met-X, Arg-X, or Leu-X bonds to release lys-bradykinin (kallidin) involved in vasodilation and smooth muscle contraction. The physiologic role of specific kallikreins is often unrelated to the kininogenase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
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