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skos:definition |
MSH: A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.,NCI: Tumor necrosis factor receptor superfamily member 14 (283 aa, ~30 kDa) is encoded by the human TNFRSF14 gene. This protein plays a role in both signal transduction and ligand binding.
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