|
skos:definition |
NCI: Expressed in prostate, testis, ovary, small intestine, and colon by human TNK1 Gene, 666-aa 72-kDa Non-Receptor Tyrosine Kinase 1 contains a putative N-terminal phosphotyrosine-binding domain, a tyrosine kinase domain, a putative SH3 domain, and a Pro-rich C-terminus containing SH3-binding motifs. The kinase domain includes an ATP-binding site and many conserved tyrosine kinase features. TNK1 shares highest homology with ACK, especially in the kinase and putative SH3 domains. Like SRC and JAK family kinases, TNK1 mediates intracellular signaling downstream of receptor activation. (NCI)
|
