|
skos:definition |
NCI: Caveolin 1 (CAV1), encoded by the CAV1 gene, is a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. In the absence of caveolin no morphologically identifiable caveolae exist, with one exception where in neuronal cells CAV 1 and CAV 2 are expressed but there are no morphologically recognizable caveolae. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. Caveolin expression is correlated both to oncogenic transformation and its reversal. CAV1 is a tumor suppressor candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. Alternative splicing results in 2 isoform proteins (alpha, beta). (NCI),NCI: Caveolin-1 is a 24 kD homooligomeric caveolar integral membrane protein that may organize signal transduction molecu
|
