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NCI: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. (from LocusLink),NCI: Encoded by human Arrestin Beta 1 Gene, 418-amino acid 47 kD Beta-Arrestin 1 (Arrestin Family) regulates Beta-Adrenergic Receptor function. Beta-Arrestins appear to bind phosphorylated Beta-Adrenergic receptors, impairing G(s) protein activation. (Swiss-Prot and NCI)
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| umls:relation |
http://linkedlifedata.com/resource/umls/relation/R54171305,
http://linkedlifedata.com/resource/umls/relation/R54421084,
http://linkedlifedata.com/resource/umls/relation/R54373458,
http://linkedlifedata.com/resource/umls/relation/R109382459,
http://linkedlifedata.com/resource/umls/relation/R54294146,
http://linkedlifedata.com/resource/umls/relation/R54373459,
http://linkedlifedata.com/resource/umls/relation/R54335365,
http://linkedlifedata.com/resource/umls/relation/R54335362,
http://linkedlifedata.com/resource/umls/relation/R54335363,
http://linkedlifedata.com/resource/umls/relation/R54335364,
http://linkedlifedata.com/resource/umls/relation/R69856098,
http://linkedlifedata.com/resource/umls/relation/R32001764,
http://linkedlifedata.com/resource/umls/relation/R69885046,
http://linkedlifedata.com/resource/umls/relation/R54599381
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