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skos:definition |
MSH: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.,NCI: DNA vaccines are used in vaccination in way that differs from those are designed to be inserted into germ line of vaccines. Therefore, this is a vaccine not a therapy for modifying genetic information (gene therapy). Direct innoculation of DNA vaccine causes expression of the recombinant DNA by cells in the inoculated host. This expression of the recombinant DNA produces protein of interest that promotes antibody, cytolytic T cell and protective immune responses.
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