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skos:definition |
NCI: p21-Activated Kinase 1, encoded by the PAK1 gene, shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling and serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined. (from Gene)
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