Linked Life Data

Pirfenidone

Source:http://linkedlifedata.com/resource/umls/id/C0298067

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NCI: A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy. It belongs to the family of drugs called anti-inflammatory agents.,PDQ: An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38334&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38334&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2635" NCI Thesaurus),NCI: An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxy
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