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skos:definition |
NCI: Ribonucleoside-Diphosphate Reductase M2 Chain, encoded by the RRM2 gene, is a subunit of ribonucleoside-diphosphate reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as M2 subunits. RRM2 gene amplification from a homogeneous staining chromosome region and altered transcription regulation is associated with drug resistance. (From LocusLink and NCI)
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0602972,
umls-label:A0602978,
umls-label:A1375183,
umls-label:A1375184,
umls-label:A1375185,
umls-label:A7587060,
umls-label:A7593555,
umls-label:A7616581,
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umls-label:A7618682,
umls-label:A7618685,
umls-label:A7618686
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R32156601,
http://linkedlifedata.com/resource/umls/relation/R32156602,
http://linkedlifedata.com/resource/umls/relation/R32156603,
http://linkedlifedata.com/resource/umls/relation/R128563928,
http://linkedlifedata.com/resource/umls/relation/R124601075,
http://linkedlifedata.com/resource/umls/relation/R54187531,
http://linkedlifedata.com/resource/umls/relation/R54373627,
http://linkedlifedata.com/resource/umls/relation/R54421123,
http://linkedlifedata.com/resource/umls/relation/R54171786,
http://linkedlifedata.com/resource/umls/relation/R54171784,
http://linkedlifedata.com/resource/umls/relation/R54171787,
http://linkedlifedata.com/resource/umls/relation/R54373629,
http://linkedlifedata.com/resource/umls/relation/R54335560,
http://linkedlifedata.com/resource/umls/relation/R54335561,
http://linkedlifedata.com/resource/umls/relation/R69714581,
http://linkedlifedata.com/resource/umls/relation/R54373628,
http://linkedlifedata.com/resource/umls/relation/R124603275,
http://linkedlifedata.com/resource/umls/relation/R54294370,
http://linkedlifedata.com/resource/umls/relation/R109382873,
http://linkedlifedata.com/resource/umls/relation/R69755632,
http://linkedlifedata.com/resource/umls/relation/R26903691,
http://linkedlifedata.com/resource/umls/relation/R69883002
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