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skos:definition |
NCI: Breast cancer type 2 susceptibility protein (3418 aa, ~384 kDa) is encoded by the human BRCA2 gene. This protein plays a role in both cell cycle regulation and DNA repair.,MSH: A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
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