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skos:definition |
NCI: Expressed in myeloid, B-, and T-cell lineages by human TEC Gene (TEC Tyr Kinase Family), 631-aa 74-kDa TEC Protein Tyrosine Kinase, a non-receptor protein-tyrosine kinase a containing a PH domain, an SH2 domain, and an SH3 domain, is an integral component of T cell signaling in T cell activation and regulation of immune functions. Human TEC is 60% homologous to mouse Tsk/ltk and 57% homologous to human BTK. Beyond the SH3, SH2, and kinase domains, the TEC family homology involves an N-terminal family-specific domain. TEC is associated with myelodysplastic syndrome. (NCI)
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