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skos:definition |
CSP: cyclin dependent kinase inhibitor which prevents cells from progressing into S phase of the cell cycle; also, causes a G1 block to cell cycle progression in response to antimitogenic stimuli or other environmental cues.,NCI: Cyclin-dependent kinase inhibitor 1 (164 aa, ~18 kDa) is encoded by the human CDKN1A gene. This protein is involved in cell cycle arrest.,MSH: A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.
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