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skos:definition |
NCI: An immunotoxin consisting of a murine anti-CD5 monoclonal antibody conjugated to the ricin A chain. The anti-CD5 monoclonal antibody component binds to CD5, a T-cell associated antigen, thereby targeting the delivery of the cytotoxic ricin A chain to T-cells. The ricin A chain component binds to T-cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)
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