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NCI: Cancer (1) has spread beyond the seminal vesicles to nearby tissue or organs, such as the rectum, bladder, or pelvic wall; or (2) has spread to nearby lymph nodes; and may have spread to the seminal vesicles or to nearby tissue or organs, such as the rectum, bladder, or pelvic wall; or (3) has spread to distant parts of the body, which may include lymph nodes or bones. Also, the prostate-specific antigen (PSA) can be any level and the Gleason score can range from 2 to 10.,NCI: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, Any N, M1) (Any G). T4: Tumor is fixed or invades adjacent structures other than seminal vesicles: bladder neck, external sphincter, rectum, levator muscles, and/or pelvic wall. N1: Metastasis in regional lymph node(s). M1: Distant metastasis. (AJCC 6th ed.) - 2003
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