| umls-concept:C0253355 | skos:definition | NCI: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.,PDQ: A synthetic noncardiotoxic aza-anthracenedione analogue. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269678&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269678&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26663" NCI Thesaurus),NCI: A synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. | lld:umls |
