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NCI: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.,PDQ: A synthetic noncardiotoxic aza-anthracenedione analogue. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269678&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269678&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26663" NCI Thesaurus),NCI: A synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.
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http://linkedlifedata.com/resource/umls/relation/R60457378,
http://linkedlifedata.com/resource/umls/relation/R22547253,
http://linkedlifedata.com/resource/umls/relation/R22547255,
http://linkedlifedata.com/resource/umls/relation/R22547252,
http://linkedlifedata.com/resource/umls/relation/R22547254,
http://linkedlifedata.com/resource/umls/relation/R32154336,
http://linkedlifedata.com/resource/umls/relation/R128554332,
http://linkedlifedata.com/resource/umls/relation/R123531296,
http://linkedlifedata.com/resource/umls/relation/R54186477,
http://linkedlifedata.com/resource/umls/relation/R54186478,
http://linkedlifedata.com/resource/umls/relation/R54186479,
http://linkedlifedata.com/resource/umls/relation/R54186476,
http://linkedlifedata.com/resource/umls/relation/R99710110,
http://linkedlifedata.com/resource/umls/relation/R114973021,
http://linkedlifedata.com/resource/umls/relation/R69771597,
http://linkedlifedata.com/resource/umls/relation/R44042034
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