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skos:definition |
MSH: Simultaneous resistance to several structurally and functionally distinct drugs.,NCI: Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective.,CSP: characteristic of certain cancer cells and infectious microorganisms, where resistance develops to a broad variety of chemically unrelated drugs; may be due to genetic induction of a membrane pump (P glycoprotein) or other mechanisms.,NCI: Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.
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