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skos:definition |
NCI: Expressed in neural and neuroendocrine tissues by human RTN1 Gene (Reticulon Family), 3 isoforms (A, B, C) of Reticulon 1, with unique N termini, are localized to ER membranes and contain a reticulon domain and 2 large C-terminal hydrophobic domains. RTN1 may be involved in neuroendocrine secretion or membrane trafficking. RTN1-A is a 776-aa 135-kD Ser/Pro-rich protein that contains multiple potential phosphorylation sites; RTN1-B is 356-aa and RTN1-C is 208-aa. RTN1-A and RTN1-B are phosphorylated and expression of RTN1-C is strongly correlated with neuronal differentiation. (NCI)
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