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skos:definition |
CSP: proteins in the cytoplasm or nucleus that specifically bind signaling molecules and trigger changes which influence the behavior of cells; major groups are the steroid hormone receptors, which usually are found in the cytoplasm, and the thyroid hormone receptors, which usually are found in the nucleus; not all cytoplasmic receptors are tree'd under this term.,NCI: Cytoplasmic Receptors are selective binding proteins that mediate the physiologic effects of specific bound regulatory molecules, such as hormones that cause a conformational and functional change in the receptor molecule. Interaction of the ligand-bound receptor with target molecules is altered, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. Steroid receptors are cytoplasmic carriers that translocate to the nucleus upon ligand binding and regulate the expression of specific target genes.
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