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skos:definition |
NCI: The AKT2 oncogene encodes RAC-beta protein kinase, belonging to a serine/threonine kinase subfamily containing SH2-like domains. The AKT2 isoform of PI-dependent protein kinase Akt is enriched in insulin-responsive tissues and may function in the metabolic actions of that hormone. Glucose homeostasis depends on insulin responsiveness in target tissues. Insulin induces phosphorylation of scaffolding proteins and activation of PI3-kinase, which activate Akt. A deficiency of Akt2 impairs the ability of insulin to lower blood glucose and may function in the maintenance of normal glucose homeostasis. (from OMIM 164731 and NCI)
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