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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.,CSP: heterodimeric cytokine that stimulates the production of interferon gamma from T-cells and natural killer cells, and also induces differentiation of Th1 helper cells; it is an initiator of cell-mediated immunity.,PDQ: A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42153&i
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skos:inScheme |
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skos:broader |
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skos:narrower |
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skos-xl:prefLabel |
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skos-xl:altLabel |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R64572680,
http://linkedlifedata.com/resource/umls/relation/R44026547,
http://linkedlifedata.com/resource/umls/relation/R64572679,
http://linkedlifedata.com/resource/umls/relation/R120566500,
http://linkedlifedata.com/resource/umls/relation/R120566501,
http://linkedlifedata.com/resource/umls/relation/R120566503,
http://linkedlifedata.com/resource/umls/relation/R120566504,
http://linkedlifedata.com/resource/umls/relation/R120566505,
http://linkedlifedata.com/resource/umls/relation/R120566506,
http://linkedlifedata.com/resource/umls/relation/R120566507,
http://linkedlifedata.com/resource/umls/relation/R120566508,
http://linkedlifedata.com/resource/umls/relation/R120566510,
http://linkedlifedata.com/resource/umls/relation/R120566511,
http://linkedlifedata.com/resource/umls/relation/R120566512,
http://linkedlifedata.com/resource/umls/relation/R120566513,
http://linkedlifedata.com/resource/umls/relation/R120566515,
http://linkedlifedata.com/resource/umls/relation/R120566516,
http://linkedlifedata.com/resource/umls/relation/R120566517,
http://linkedlifedata.com/resource/umls/relation/R120566519,
http://linkedlifedata.com/resource/umls/relation/R120566520,
http://linkedlifedata.com/resource/umls/relation/R120566521,
http://linkedlifedata.com/resource/umls/relation/R120566522,
http://linkedlifedata.com/resource/umls/relation/R120566523,
http://linkedlifedata.com/resource/umls/relation/R120566524,
http://linkedlifedata.com/resource/umls/relation/R120566525,
http://linkedlifedata.com/resource/umls/relation/R120566526,
http://linkedlifedata.com/resource/umls/relation/R120566527,
http://linkedlifedata.com/resource/umls/relation/R120566528,
http://linkedlifedata.com/resource/umls/relation/R120566529,
http://linkedlifedata.com/resource/umls/relation/R120566530,
http://linkedlifedata.com/resource/umls/relation/R120566514,
http://linkedlifedata.com/resource/umls/relation/R120566502,
http://linkedlifedata.com/resource/umls/relation/R120566518
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