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skos:definition |
MSH: Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene protein c-fos codes for a nuclear protein which is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-31 on the long arm of chromosome 14.,NCI: FOS Family Genes encode nuclear leucine zipper FOS Family Proteins (FOS, FOSB, FOSL1, and FOSL2) that can dimerize with JUN Family proteins and bind DNA as the AP-1 transcription factor complex to regulate transcription in cell proliferation, differentiation, and transformation. (NCI)
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