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skos:definition |
MSH: Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.,NCI: Encoded by JUN Family Genes, nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA-binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation. (NCI),NCI: JUN protein is encoded by the serum-induced human c-JUN Gene (JUN Family) at 1p32-p31, dimeric DNA-binding JUN Protein (331-aa, 35.7-kDa) is involved in growth-related transcriptional control. JUN appears to comprise three distinct functions: leucine zipper dimerization (with c-FOS) to form enhancer-binding pro
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