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skos:definition |
MSH: A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.,PDQ: The carbonate salt of lithium, a monovalent cation with antimanic activity. Lithium carbonate interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium carbonate exerts its mood-stabilizing effect has not been established. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39491&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39491&idtype=1&closed=1" closed clinical trials using this ag
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