|
skos:definition |
MSH: A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.,CSP: specialized DNA-protein structures found at the ends of eukaryotic chromosomes with the function of stabilizing chromosomes; telomerase is the RNA-dependent DNA polymerase responsible for the synthesis of telomere DNA.,GO: OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA. [ISBN:0198506732, PMID:11352055],NCI: The ends of a chromosome. Each time a cell divides, the telomeres lose a small amount of DNA and become shorter. Over ti
|
