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skos:definition |
MSH: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.,CSP: genetically immunodeficient mouse strain used to model human severe combined immunodeficiency syndrome and to construct experimental immunologic chimeras; the most notable artificial chimera is the SCID- hu mouse, which has a virtual human immune system.,NCI: Severe combined immunodeficient (SCID) mice like their human counterparts with immunodeficiency diseases are helpless not only to fight infection but also to reject transplanted tissue. These animals lack b
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