O6-Benzylguanine

umls-semnetwork:T114, umls-semnetwork:T121, skos:Concept

NCI: A drug that may improve the response of cancer cells to chemotherapy.,NCI: A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04),PDQ: A guanine analogue with antineoplastic activity. O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42113&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42113&idtype=1&closed=1" closed clinical

umls-concept:C0003392, umls-concept:C0014432, umls-concept:C0018321

umls-label:A0211914, umls-label:A0755102, umls-label:A10763272, umls-label:A10782772, umls-label:A10782775, umls-label:A10783856, umls-label:A10786994, umls-label:A10786995, umls-label:A10789964, umls-label:A11915998, umls-label:A11916722, umls-label:A11918330, umls-label:A11919143, umls-label:A12816115, umls-label:A12816116, umls-label:A12998170, umls-label:A1302420, umls-label:A18587095, umls-label:A18698409, umls-label:A4344006, umls-label:A4362185