|
skos:definition |
MSH: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.,CSP: family of transcription factors involved in cytokine-induced activation of gene expression by binding to the enhancer; essential for HIV expression.,NCI: NF-kB is a heterodimer complex of two DNA-binding subunits from two families of ubiquitous, inducible, nuclear transcription activators involved in cytokine-induced activation of gene expression. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-kB complex. NF-kB is inhibited by IkB proteins (NFKBIA or NFKBIB), which inactivate NF-kB by trapping it in the cytoplasm. Phosphorylation of IkB by kinases (IKBKA or IKBKB) marks them for ubiquitination, allowing NF-kB translocation to the nucleus and DNA binding at kappa-B transcription enhancer motifs. In B-lymphocytes, NF-kB binds to the i
|
