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skos:definition |
PDQ: A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39575&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39575&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1208" NCI Thesaurus),NCI: A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R43993177,
http://linkedlifedata.com/resource/umls/relation/R32113145,
http://linkedlifedata.com/resource/umls/relation/R28115273,
http://linkedlifedata.com/resource/umls/relation/R28115274,
http://linkedlifedata.com/resource/umls/relation/R28115275,
http://linkedlifedata.com/resource/umls/relation/R28115276,
http://linkedlifedata.com/resource/umls/relation/R128461168,
http://linkedlifedata.com/resource/umls/relation/R28115272,
http://linkedlifedata.com/resource/umls/relation/R60457594,
http://linkedlifedata.com/resource/umls/relation/R109631500,
http://linkedlifedata.com/resource/umls/relation/R69880163,
http://linkedlifedata.com/resource/umls/relation/R69796402,
http://linkedlifedata.com/resource/umls/relation/R48468124,
http://linkedlifedata.com/resource/umls/relation/R40659586
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