Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| calbc:hasCorrelation | |
| skos:definition |
PDQ: A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39206&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39206&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1161" NCI Thesaurus),NCI: A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capab
|
| skos:inScheme | |
| skos:broader | |
| skos:narrower | |
| skos-xl:prefLabel | |
| skos-xl:altLabel | |
| umls:relation |
http://linkedlifedata.com/resource/umls/relation/R32115422,
http://linkedlifedata.com/resource/umls/relation/R32115423,
http://linkedlifedata.com/resource/umls/relation/R32115424,
http://linkedlifedata.com/resource/umls/relation/R28115696,
http://linkedlifedata.com/resource/umls/relation/R28115697,
http://linkedlifedata.com/resource/umls/relation/R28115698,
http://linkedlifedata.com/resource/umls/relation/R128463420,
http://linkedlifedata.com/resource/umls/relation/R129066837,
http://linkedlifedata.com/resource/umls/relation/R60461443,
http://linkedlifedata.com/resource/umls/relation/R60455287,
http://linkedlifedata.com/resource/umls/relation/R60454165,
http://linkedlifedata.com/resource/umls/relation/R124699971,
http://linkedlifedata.com/resource/umls/relation/R69806853,
http://linkedlifedata.com/resource/umls/relation/R69751565,
http://linkedlifedata.com/resource/umls/relation/R40659500
|