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skos:definition |
CSP: retrovirus encoded protein which covalently links the viral cDNA to host DNA; forms a 'preintegration complex' and catalyzes the viral integration reaction.,MSH: Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.,NCI: Integrase is an enzyme that catalyzes the integration of viral DNA into the host genome. These enzymes act to cleave and religate the joints between host DNA and integrated DNA.
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