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skos:definition |
MSH: Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.,CSP: newly identified and characterized growth factor; involved in regulating cell migration.,NCI: Human Hepatocyte Growth Factor is also known as Scatter Factor and Hepatopoeitin A. HGF is a potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types, including renal tubular epithelial cells, epidermal keratinocytes and melanocytes. A single chain precursor is cleaved to 70 kD and 30kD chains that are linked by one disulfide bond. Both the single chain and cleaved form are active.
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