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skos:definition |
CSP: 5 azacytosine arabinoside; USP lists as an antineoplastic agent.,NCI: An anticancer drug that is a type of antimetabolite.,PDQ: An orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40564&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40564&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1096" NCI Thesaurus),NCI: An orally-active pyrimidine analogue of an
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