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skos:definition |
MSH: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.,NCI: Neurotransmission mediated by the Dopamine D2 Receptor (DRD2) plays a key role in the control of movement, in reward and reinforcement mechanisms in psychiatric disorders, and in the neuromodulation of appetitive behaviors. Acting through D2 dopamine receptors, dopamine specifically inhibits the vascular permeabilizing and angiogenic activities of VEGF by inducing endocytosis of VEGF receptor 2, preventing VEGF binding, receptor phosphorylation, and signaling. (from OMIM 126450 and NCI)
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