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skos:definition |
MSH: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.,CSP: plasma glycoprotein associated with Factor VIII; important in clotting and hemostatic plug formation.,NCI: Von Willebrand factor (2,813 aa, 309 kD) is a cell adhesion process protein that is encoded by the human VWF gene and has roles in platelet activation and cell-substrate adhesion.
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