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skos:definition |
MSH: Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.,NCI: A trisaziridine alkylating agent with antineoplastic and carcinogenic properties. Used to induce cancer in experimental animal models, triethylenemelamine ethylates DNA, resulting in inhibition of DNA replication, unscheduled DNA synthesis, chromosomal aberrations, and sister chromatid exchanges. This agent also exhibits reproductive toxicities. (NCI04)
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