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skos:definition |
MSH: An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.,NCI: A protein involved in making and repairing DNA (molecules inside cells that carry genetic information and pass it on from parent to child). High levels of thymidylate synthase may be involved in how certain types of cancer form and respond to treatment.,NCI: Thymidylate synthetase protein (312 aa, ~36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes methylene tetrahydrofolate (MTHF)/dUMP conversion to dihydrofolate/dTMP in thymidine triphosphate/deoxyribonucleotide biosynthesis. Thymidylate synthetase competes with the methylene tetrahydrofolate receptor for MTHF and maintains the dTMP pool for DNA replication and repair.
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