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skos:definition |
MSH: Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.,NCI: A nucleolar, HIV-encoded transcriptional regulator that binds to the RNA Trans-Activating Responsive (TAR) sequence. TAT activates transcription initiation and/or elongation from the LTR promoter. TAT may bind Cyclin T1. (from SWISS-PROT P24738 and NCI)
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