|
skos:definition |
MSH: Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.,CSP: major vehicle for cellular uptake of iron; receptor expression is tightly regulated by available iron, via an "iron-responsive element" (IRE) on its mRNA which prevents translation when occupied by an iron- sensitive binding protein.,NCI: Homodimeric human Transferrin Receptors (M28B Peptidase Family) are type II membrane proteins involved in the cellular import of transferrin-bound iron and appear necessary for iron metabolism, cell function, and erythrocyte differentiation. (NCI)
|
