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skos:definition |
MSH: Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.,NCI: Expressed on T- and B-cells, human heterodimeric High Affinity Interleukin-2 Receptor consists of IL2RA and IL2RB subunits, associated with a common IL2RG chain, and mediates IL2 mitogenic signaling. Homodimeric IL2RA chains constitute a low-affinity non-signaling receptor, while homodimeric IL2RB chains produce a medium-affinity signaling receptor. IL2RG comprises a signaling component of many interleukin receptors (IL2, IL4, IL7, IL9, and IL15). (NCI)
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