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NCI: From the Sigmodon genus of rodents, Sigmodon hispidus was the first animal model to be used in polio research. The cotton rat has a stout body, small ears and a dark coat that can be dark brown or mixed buff and black, with a tail length that is 35% of its total body length. As its name suggests, this breed has a proclivity for cotton in its nesting, and is a natural Hanta viral reservoir. The cotton rat has wide applications in viral research.,NCI: The rat of the genus and species Sigmodon hispidus.
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