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skos:definition |
MSH: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.,CSP: plasma protein precursor of thrombin, converted to thrombin by a prothrombin activator complex; deficiency of prothrombin leads to hypoprothrombinemia.,NCI: Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen.
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