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skos:definition |
MSH: (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.,CSP: prostaglandin E2 is the most common and most biologically active of the mammalian prostaglandins; it exhibits most biological activities characteristic of prostaglandins including vasodilation, immune modulatory effects, contraction or relaxation of smooth muscle, inhibition of gastric secretion and sodium resorption inhibition; it has been used extensively as an oxytocic agent and displays a protective effect on the intestinal mucosa; prostaglandin E1
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